Photo header-page0001


Turner L, Munsie M, Levine AD, Ikonomou L. (2021). Ethical issues and public communication in the development of cell-based treatments for COVID-19: Lessons from the pandemic. Stem Cell Reports. 16(11):2567-2576. doi: 10.1016/j.stemcr.2021.09.005.

Posabella, A., Alber, A.B., Undeutsch, H.J., Droeser, R.A., Hollenberg, A.N., Ikonomou, L., and Kotton, D.N. (2021). Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine. Front. Endocrinol. 12, 16, 666565. 10.3389/fendo.2021.666565.

Khoury, M., Ikonomou, L., Dominici, M., LeBlanc, K., Levine, B.L., and Weiss, D.J. (2021). The Coronavirus Pandemic: A Pitfall or a Fast Track for Validating Cell Therapy Products? Stem Cells Dev. 30, 119-127. 10.1089/scd.2020.0122.

Ikonomou, L. (2021). The Coming-of-Age of Lung Generation by Blastocyst Complementation. Am. J. Respir. Crit. Care Med. 203, 408-410. 10.1164/rccm.202009-3548ED.

Ellis, L.V., and Ikonomou, L. (2021). All Roads Lead to Rome? Resident or Interspecies Chimera-derived Pulmonary Endothelial Progenitors for Cell-based Therapy. Am. J. Respir. Crit. Care Med. 204, 251-252. 10.1164/rccm.202103-0786ED.


Wagner, D.E., Ikonomou, L., Gilpin, S.E., Magin, C.M., Cruz, F., Greaney, A., Magnusson, M., Chen, Y.W., Davis, B., Vanuytsel, K., et al. (2020). Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019. ERJ Open Res. 6, 15, 00123-2020. 10.1183/23120541.00123-2020.

Ikonomou, L., and Weiss, D.J. (2020). Turning the Tide on Unproven Cell-Based Interventions. Chest 157, 774-775. 10.1016/j.chest.2019.10.035.

Ikonomou, L., Wagner, D.E., Gilpin, S.E., Weiss, D.J., and Ryan, A.L. (2020b). Technological advances in study of lung regenerative medicine: perspective from the 2019 Vermont lung stem cell conference. Cytotherapy 22, 519-520. 10.1016/j.jcyt.2020.04.001.

Ikonomou, L., Herriges, M.J., Lewandowski, S.L., Marsland, R., Villacorta-Martin, C., Caballero, I.S., Frank, D.B., Sanghrajka, R.M., Dame, K., Kandula, M.M., et al. (2020a). The in vivo genetic program of murine primordial lung epithelial progenitors. Nat. Commun. 11, 17, 635. 10.1038/s41467-020-14348-3.

Hoffman, E.T., Pouliot, R., Alysandratos, K., Ikonomou, L., Kotton, D., and Weiss, D.J. (2020). Alveolar Extracellular Matrix Hydrogels Facilitate Proliferation of Induced Pluripotent StemCell-Derived Alveolar Epithelial Spheroids. Cytotherapy 22, S204-S204.


Ryan, A.L., Ikonomou, L., Atarod, S., Bolukbas, D.A., Collins, J., Freishtat, R., Hawkins, F., Gilpin, S.E., Uhl, F.E., Uriarte, J.J., et al. (2019). Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017 An Official American Thoracic Society Workshop Report. Am. J. Respir. Cell Mol. Biol. 61, 429-439. 10.1165/rcmb.2019-0286ST.

Ikonomou, L., Wagner, D.E., Turner, L., and Weiss, D.J. (2019). Translating Basic Research into Safe and Effective Cell-based Treatments for Respiratory Diseases. Ann. Am. Thoracic Society 16, 657-668. 10.1513/AnnalsATS.201812-890CME.]


Weiss, D.J., Turner, L., Levine, A.D., and Ikonomou, L. (2018). Medical societies, patient education initiatives, public debate and marketing of unproven stem cell interventions. Cytotherapy 20, 165-168. 10.1016/j.jcyt.2017.10.002.

Wagner, D.E., Turner, L., Panoskaltsis-Mortari, A., Weiss, D.J., and Ikonomou, L. (2018). Co-opting of by patient-funded studies. Lancet Resp. Med. 6, 579-581. 10.1016/s2213-2600(18)30242-x.

Wagner, D.E., Turner, L., Panoskaltsis-Mortari, A., Weiss, D.J., and Ikonomou, L. (2018). Co-opting of by patient-funded studies. Lancet Resp. Med. 6, 579-581. 10.1016/s2213-2600(18)30242-x.

Lenas, P., and Ikonomou, L. (2018). Developmental engineering: design of clinically efficacious bioartificial tissues through developmental and systems biology. Sci. China-Life Sci. 61, 978-981. 10.1007/s11427-017-9255-3.

Jamal, M., Lewandowski, S.L., Lawton, M.L., Huang, G.T.J., and Ikonomou, L. (2018). Derivation and characterization of putative craniofacial mesenchymal progenitor cells from human induced pluripotent stem cells. Stem Cell Res. 33, 100-109. 10.1016/j.scr.2018.10.015.

Cuende, N., Rasko, J.E.J., Koh, M.B.C., Dominici, M., and Ikonomou, L. (2018). Cell, tissue and gene products with marketing authorization in 2018 worldwide. Cytotherapy 20, 1401-1413. 10.1016/j.jcyt.2018.09.010.


Serra, M., Alysandratos, K.D., Hawkins, F., McCauley, K.B., Jacob, A., Choi, J., Caballero, I.S., Vedaie, M., Kurmann, A.A., Ikonomou, L., et al. (2017). Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification. Development 144, 3879-3893. 10.1242/dev.150193.

Dame, K., Cincotta, S., Lang, A.H., Sanghrajka, R.M., Zhang, L.Y., Choi, J.Y., Kwok, L., Wilson, T., Kandula, M.M., Monti, S., et al. (2017). Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1. Stem Cell Rep. 8, 216-225. 10.1016/j.stemcr.2016.12.024.


Ikonomou, L., Freishtat, R.J., Wagner, D.E., Panoskaltsis-Mortari, A., and Weiss, D.J. (2016). The Global Emergence of Unregulated Stem Cell Treatments for Respiratory Diseases Professional Societies Need to Act. Ann. Am. Thoracic Society 13, 1205-1207. 10.1513/AnnalsATS.201604-277ED.


Kurmann, A.A., Serra, M., Hawkins, F., Rankin, S.A., Mori, M., Astapova, I., Ullas, S., Lin, S., Bilodeau, M., Rossant, J., et al. (2015). Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells. Cell Stem Cell 17, 527-542. 10.1016/j.stem.2015.09.004.

Ikonomou, L., and Kotton, D.N. (2015). Derivation of Endodermal Progenitors From Pluripotent Stem Cells. J. Cell. Physiol. 230, 246-258. 10.1002/jcp.24771.


Longmire, T.A., Ikonomou, L., Hawkins, F., Christodoulou, C., Cao, Y.X., Jean, J.C., Kwok, L.W., Mou, H.M., Rajagopal, J., Shen, S.S., et al. (2012). Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells. Cell Stem Cell 10, 398-411. 10.1016/j.stem.2012.01.019.

Diaz, P.I., Xie, Z.H., Sobue, T., Thompson, A., Biyikoglu, B., Ricker, A., Ikonomou, L., and Dongari-Bagtzoglou, A. (2012). Synergistic Interaction between Candida albicans and Commensal Oral Streptococci in a Novel In Vitro Mucosal Model. Infect. Immun. 80, 620-632. 10.1128/iai.05896-11.


Ikonomou, L., Hemnes, A.R., Bilousova, G., Hamid, R., Loyd, J.E., Hatzopoulos, A.K., Kotton, D.N., Majka, S.M., and Austin, E.D. (2011). Programmatic change: lung disease research in the era of induced pluripotency. Am. J. Physiol.-Lung Cell. Mol. Physiol. 301, L830-L835. 10.1152/ajplung.00255.2011.

Hawkins, F.J., Longmire, T., Oikonomou, L., and Kotton, D.N. (2011). Directed Differentiation Of Mouse Embryonic Stem Cells Into Primordial Lung Progenitor Cells. Am. J. Respir. Crit. Care Med. 183, 1.

Ott, H.C., Clippinger, B., Conrad, C., Schuetz, C., Pomerantseva, I., Ikonomou, L., Kotton, D., and Vacanti, J.P. (2010). Regeneration and orthotopic transplantation of a bioartificial lung. Nat. Med. 16, 927-U131. 10.1038/nm.2193.

Kotova, S., Vijayasarathy, C., Dimitriadis, E.K., Ikonomou, L., Jaffe, H., and Sieving, P.A. (2010). Retinoschisin (RS1) Interacts with Negatively Charged Lipid Bilayers in the Presence of Ca2+: An Atomic Force Microscopy Study. Biochemistry 49, 7023-7032. 10.1021/bi1007029.


Davani, B., Ariely, S., Ikonomou, L., Oron, Y., and Gershengorn, M.C. (2009). Human islet-derived precursor cells can cycle between epithelial clusters and mesenchymal phenotypes. J. Cell. Mol. Med. 13, 2570-2581. 10.1111/j.1582-4934.2008.00570.x.


Lenas, P., Moreno, A., Ikonomou, L., Mayer, J., Honda, H., Novellino, A., Pizarro, C., Nicodemou-Lena, E., Rodergas, S., and Pintor, J. (2008). The complementarity of the technical tools of tissue engineering and the concepts of artificial organs for the design of functional bioartificial tissues. Artif. Organs 32, 742-747. 10.1111/j.1525-1594.2008.00599.x.

Ikonomou, L., Geras-Raaka, E., Raaka, B.M., and Gershengorn, M.C. (2008). Beta-catenin signalling in mesenchymal islet-derived precursor cells. Cell Prolif. 41, 474-491. 10.1111/j.1365-2184.2008.00527.x.


Davani, B., Ikonomou, L., Raaka, B.M., Geras-Raaka, E., Morton, R.A., Marcus-Samuels, B., and Gershengorn, M.C. (2007). Human islet-derived precursor cells are mesenchymal stromal cells that differentiate and mature to hormone-expressing cells in vivo. Stem Cells 25, 3215-3222. 10.1634/stemcells.2007-0323.


Ikonomou, L., Bastin, G., Schneider, Y.J., and Agathos, S.N. (2004). Effect of partial medium replacement on cell growth and protein production for the High-Five (TM) insect cell line. Cytotechnology 44, 67-76. 10.1023/B:CYTO.0000043413.53044.fa.


Ikonomou, L., Schneider, Y.J., and Agathos, S.N. (2003). Insect cell culture for industrial production of recombinant proteins. Appl. Microbiol. Biotechnol. 62, 1-20. 10.1007/s00253-003-1223-9.


Ikonomou, L., Peeters-Joris, C., Schneider, Y.J., and Agathos, S.N. (2002b). Supernatant proteolytic activities of High-Five insect cells grown in serum-free culture. Biotechnol. Lett. 24, 965-969. 10.1023/a:1015692323167.

Ikonomou, L., Drugmand, J.C., Bastin, G., Schneider, Y.J., and Agathos, S.N. (2002a). Microcarrier culture of lepidopteran cell lines: Implications for growth and recombinant protein production. Biotechnol. Prog. 18, 1345-1355. 10.1021/bp0255107.


Ikonomou, L., Bastin, G., Schneider, Y.J., and Agathos, S.N. (2001). Design of an efficient medium for insect cell growth and recombinant protein production. In Vitro Cell. Dev. Biol.-Anim. 37, 549-559.

For a comprehensive list of our publications, please click here